Ideas about the mechanisms that regulate chromosome pairing, recombination, and segregation during meiosis have gained in molecular detail over the last few years. The purpose of this article is to survey briefly the shifts in paradigms and experiments that have generated new perspectives. It has never been very clear what it is that brings together the homologous chromosomes at meiotic prophase. For a while it appeared that the synaptonemal complex might be the nuclear organelle responsible for synapsis, but the supporting (...) evidence has not been entirely convincing. Whatever the mechanism, it has always been assumed that homologous synapsis creates the opportunity for homologous DNA sequences to initiate recombination. At present, alternative ideas are developing. Attractive is the concept that double strand DNA repair mechanisms, that find and use the undamaged homologue for repair, have evolved into a meiotic mechanism for the recognition and pairing of homologous sequences. Subsequent intimate synapsis of homologous chromosomes in the context of the synaptonemal complex may serve later functions in the regulation of interference and segregation at first anaphase. A number of areas that are being tested at present and some that may be investigated in the future are discussed at the end of the review. (shrink)

Several DNA-damage detection and repair mechanisms have evolved to repair double-strand breaks induced by mutagens. Later in evolutionary history, DNA single- and double-strand cuts made possible immune diversity by V(D)J recombination and recombination at meiosis. Such cuts are induced endogenously and are highly regulated and controlled. In meiosis, DNA cuts are essential for the initiation of homologous recombination, and for the formation of joint molecule and crossovers. Many proteins that function during somatic DNA-damage detection and repair are also active during (...) homologous recombination. However, their meiotic functions may be altered from their somatic roles through localization, posttranslational modifications and/or interactions with meiosis-specific proteins. Presumably, somatic repair functions and meiotic recombination diverged during evolution, resulting in adaptations specific to sexual reproduction. BioEssays 27:795–808, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Fluorescent in situ hybridization technology is one of the most exciting and versatile research tools to be developed in recent years. It has enabled research to progress at a phenomenal rate in diverse areas of basic research as well as in clinical medicine. Fluorescent in situ hybridization has applications in physical mapping, the study of nuclear architecture and chromatin packaging, and the investigation of fundamental principles of biology such as DNA replication, RNA processing, gene amplification, gene integration and chromatin elimination. (...) This review highlights some of these areas and provides source material for the reader who seeks more information on a specific field. (shrink)

Ever since ecology's inception, the concept of competition has generated discussion. Recent discussions have focused on the role of interspecific competition in shaping the structure of ecological communities. More in particular, ecologists are split up over the validity of a method that is currently in vogue to discredit explanations of community structure in terms of competition theory. An analysis of this controversy is presented which attempts to show that the discussions so far have focused on the wrong issues. Not the (...) method's ability to generate alternative explanations should be questioned, but its ability to generate superior explanations. The impact of Popperian philosophy of science on the dispute is briefly discussed. (shrink)

1.1 All mental terms are defined by private ostensive definition. 1.1.1 For example, the word "red" used to denote the conscious colour experience of red, as opposed to red light or red paint, is defined by attending to a red sensation and designating it "red".

volume 1. Developing institutional theory -- volume 2. New research agendas -- volume 3. Applying institutional theory.

Sep 17 Time travel in Special Relativity (1) Nahin 1999: 439-51 & 459-66; (2) Taylor & Wheeler 1992: 121-35; (3) Nahin 1999: 343-8. Sep 24 Time travel in General Relativity (1) Malament 1985: 91-5; (2) Thorne 1994: 483-90 & 498-521; (3) Gott 2001: 92-110. Oct 1 Time travel in Quantum Mechanics (1) Albert 1992: 17-38, 73-9, & 112-5; (2) Barrett 1999: 149-62; (3) Deutsch & Lockwood 1994.

Imperatives cannot be true or false, so they are shunned by logicians. And yet imperatives can be combined by logical connectives: "kiss me and hug me" is the conjunction of "kiss me" with "hug me". This example may suggest that declarative and imperative logic are isomorphic: just as the conjunction of two declaratives is true exactly if both conjuncts are true, the conjunction of two imperatives is satisfied exactly if both conjuncts are satisfied—what more is there to say? Much more, (...) I argue. "If you love me, kiss me", a conditional imperative, mixes a declarative antecedent ("you love me") with an imperative consequent ("kiss me"); it is satisfied if you love and kiss me, violated if you love but don't kiss me, and avoided if you don't love me. So we need a logic of three -valued imperatives which mixes declaratives with imperatives. I develop such a logic. (shrink)

If Y is normal with parameters μ and σ , the standard normal Z = ( Y - μ )/ σ has parameters and 1. Central Limit Theorem: For any sequence Y 1, Y 2, ... of IID random variables with expectation μ and variance σ , the cdf of Z is the limit, as n → ∞, of the cdf of ( Y 1 + Y 2 + … + Yn - nμ )/( σ √\x{D835}\x{DC5B}).

Why does classical equilibrium statistical mechanics work? Malament and Zabell (1980) noticed that, for ergodic dynamical systems, the unique absolutely continuous invariant probability measure is the microcanonical. Earman and Rédei (1996) replied that systems of interest are very probably not ergodic, so that absolutely continuous invariant probability measures very distant from the microcanonical exist. In response I define the generalized properties of epsilon-ergodicity and epsilon-continuity, I review computational evidence indicating that systems of interest are epsilon-ergodic, I adapt Malament and Zabell’s (...) defense of absolute continuity to support epsilon-continuity, and I prove that, for epsilon-ergodic systems, every epsilon-continuous invariant probability measure is very close to the microcanonical. (shrink)

Amit Goswami published his book, "The Self-Aware Universe: How Consciousness Creates the Material World", in 1993. In 1996, he and Henry Swift started up the online newsletter Science Within Consciousness, which carries articles and news features connected with the Goswamian philosophy. Below, I comment on Goswami 's metaphysical theories as represented in his writings in the SWC newsletter, especially in his pieces: Monistic Idealism May Provide Better Ontology for Cognitive Science: A Reply to Dyer, The Hard Question: View from A (...) Science Within Consciousness, Toward an Understanding of the Paranormal, Amit Goswami was a professor at the Institute of Theoretical Science at the University of Oregon. He taught physics for 32 years in the USA, mostly at Oregon. He now is Senior Resident Researcher at the Institute of Noetic Sciences. (shrink)

In discussing the psychiatric diagnoses, the author explores not the “formal” diagnoses of the so-called mental illnesses, but the “informal” judgments made by psychotherapists in regard to their method or the process of their therapy. These diagnoses include transference, repression, resistance, denial, negativism, projection, and suppression. While these are not precisely the symptoms of psychopathology, they are an integral part of the language which psychotherapists use to describe and label what they see as problems in their patients. These so-called problems, (...) which are interpreted by the therapist as existing within the patient, can be reinterpreted and largely avoided in philosophical counseeling.The author argues that, when a person is observed or diagnosed by a psychotherapist as exhibiting one of these supposedly problematic traits the therapist is in fact misinterpreting what is going on. (shrink)

Critiques existing theoretical approaches and practices of philosophical counseling and presents a new model.

I outline six components of a comprehensive proposal for overhauling the foundations of deontic logic. (1) Actions and prescriptions are temporally indexed; more precisely, they attach to nodes of a tree in a branching time structure. (2) Actions are (modeled as) sets of branches and can be coarse- or fine-grained depending on whether or not they have proper subsets which are also actions. (3) Prescriptions have satisfaction and violation sets; these are sets of branches which may—but need not—be or include (...) actions. (4) Prescriptive propositions, which state that an action is obligatory/permitted/forbidden according to a given prescription, are defined by relating the action with the satisfaction and violation sets of the prescription. (5) Conditional prescriptions can—but need not—be derived from unconditional or even from other conditional ones. (6) Thick prescriptions, in contrast to thin ones, prescribe or proscribe actions with varying intensities, and can have embedded subprescriptions (some of which are negative, namely “contraryto-duty”). Most of the above components are inspired by the literature, but their combination is novel. (shrink)

I defend the following version of the ought-implies-can principle: (OIC) by virtue of conceptual necessity, an agent at a given time has an (objective, pro tanto) obligation to do only what the agent at that time has the ability and opportunity to do. In short, obligations correspond to ability plus opportunity. My argument has three premises: (1) obligations correspond to reasons for action; (2) reasons for action correspond to potential actions; (3) potential actions correspond to ability plus opportunity. In the (...) bulk of the paper I address six objections to OIC: three objections based on putative counterexamples, and three objections based on arguments to the effect that OIC conflicts with the is/ought thesis, the possibility of hard determinism, and the denial of the Principle of Alternate Possibilities. (shrink)

Neuroscience has substantially advanced the understanding of how changes in brain biochemistry contribute to mechanisms of tolerance and physical dependence via exposure to addictive drugs. Many scientists and mental health advocates scaffold this emerging knowledge by adding the imprimatur of disease, arguing that conceptualizing addiction as a brain disease will reduce stigma amongst the folk. Promoting a brain disease concept is grounded in beneficent and utilitarian thinking: the language makes room for individuals living with addiction to receive the same level (...) of compassion and access to healthcare services as individuals living with other medical diseases, and promotes enlightened social and legal policies. However such claims may yield unintended consequences by fostering discrimination commonly associated with pathology. Specifically, the language of neuroscience used to describe addiction may reduce attitudes such as blame and responsibility while inadvertently identifying addicted persons as neurobiological others. In this paper, we examine the merits and limitations of adopting the language of neuroscience to describe addiction. We argue that the reframing of addiction in the language of neuroscience provides benefits such as the creation of empowered biosocial communities, but also creates a new set of risks, as descriptive neuroscience concepts are inseparable from historical attitudes and intuitions towards addiction and addicted persons. In particular, placing emphasis on the diseased brain may foster unintended harm by paradoxically increasing social distance towards the vulnerable group the term is intended to benefit. (shrink)

Besides pure declarative arguments, whose premises and conclusions are declaratives, and pure imperative arguments, whose premises and conclusions are imperatives, there are mixed-premise arguments, whose premises include both imperatives and declaratives, and cross-species arguments, whose premises are declaratives and whose conclusions are imperatives or vice versa. I propose a general definition of argument validity: an argument is valid exactly if, necessarily, every fact that sustains its premises also sustains its conclusion, where a fact sustains an imperative exactly if it favors (...) the satisfaction over the violation proposition of the imperative, and a fact sustains a declarative exactly if, necessarily, the declarative is true if the fact exists. I argue that this definition yields as special cases the standard definition of validity for pure declarative arguments and my previously defended definition of validity for pure imperative arguments, and that it yields intuitively acceptable results for mixed-premise and cross-species arguments. (shrink)

You may not know me well enough to evaluate me in terms of my moral character, but I take it you believe I can be evaluated: it sounds strange to say that I am indeterminate, neither good nor bad nor intermediate. Yet I argue that the claim that most people are indeterminate is the conclusion of a sound argument—the indeterminacy paradox—with two premises: (1) most people are fragmented (they would behave deplorably in many and admirably in many other situations); (2) (...) fragmentation entails indeterminacy. I support (1) by examining psychological experiments in which most participants behave deplorably (e.g., by maltreating “prisoners” in a simulated prison) or admirably (e.g., by intervening in a simulated theft). I support (2) by arguing that, according to certain plausible conceptions, character evaluations presuppose behavioral consistency (lack of fragmentation). Possible reactions to the paradox include: (a) denying that the experiments are relevant to character; (b) upholding conceptions according to which character evaluations do not presuppose consistency; (c) granting that most people are indeterminate and explaining why it appears otherwise. I defend (c) against (a) and (b). (shrink)

Controversies in science have a tendency to be long-lasting. Moreover, they tend to wither rather than be solved by sorting out the arguments pro and con. Barring the sociological dimension, an important factor in the perpetuation of scientific controversies seems to be the contestants' passion for broad philosophical theses when it comes to defending their respective positions. In this paper one such controversy is analysed. It involves the alleged use of Popperian falsificationism to defend a position in (community) ecology some (...) years ago. The upshot of the analysis is that falsificationism is altogether irrelevant to the controversy's solution; philosophy, though, is utterly relevant if one limits it to elementary, uncontroversial, normative methodological principles. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Wittgenstein, Tolstoy, and ShakespearePeter B. LewisNear the middle of the first of his 1938 Lectures on Aesthetics, Wittgenstein talks about what he calls "the tremendous things in art"(LC, I 23 8, italics in original).1 Apart from a brief indication of the way in which our response to the tremendous differs from the non-tremendous, he does not refer again in this way to the tremendous things in art, though he (...) does refer elsewhere to what he calls "supreme art." But he does provide a couple of examples of the tremendous in art, the symphonies of Beethoven and Gothic Cathedrals. Suppose, now, like the student in the Investigations §185, we are asked to continue the series. I take it that, even given the lack of information, we could safely propose, say, Homer—the Iliad and the Odyssey—and Michelangelo—the Sistine Chapel—as further examples of the tremendous things in art. The idea is that the tremendous things in art are not works that are just very good or very fine, but rather they are great, supremely great; works of stature; special cases; instances of the highest kind of artistic achievement, occupying a distinctive place in the history of (Western) civilization.Another obvious candidate for the list of the tremendous things in art would be Shakespeare, where the name is shorthand for the great plays, the tragedies in particular, Lear, Hamlet, Othello,and so on. So it comes as something of a surprise to discover on reading that miscellaneous compendium of remarks known as Culture and Value that Wittgenstein himself had serious doubts about including Shakespeare in the pantheon of the tremendous things in art. There are seven passages in Culture and Value in which Wittgenstein reflects on Shakespeare.2 The earliest is dated 1939–40, though this passage does not appear to be critical of Shakespeare. The next two passages are [End Page 241] dated August 1946, the remainder coming in 1949 and 1950. The remarks critical of Shakespeare are, then, all very much late Wittgenstein.It is well-known that lots of people dislike Shakespeare's plays. Generations of school children have developed indifference or boredom or hatred that persists throughout their lives. And yet that does not count against Shakespeare's greatness; for, to borrow Hume's remark on those who would prefer Ogilby to Milton, "no one pays attention to such a taste; and we pronounce without scruple the sentiment of these [people] to be absurd and ridiculous."3 That rhetoric is, however, not available, at least not immediately, when the "pretended critic" (Hume's phrase) has the intellectual clout and aesthetic sensibility of a Wittgenstein; nor, for that matter, the artistic achievement of a Tolstoy.I have particular grounds for bringing Tolstoy into this discussion. In the first place, there is the importance of Tolstoy in the development of Wittgenstein's thinking about religious, moral and aesthetic issues. Secondly, it is by contrast with Tolstoy's criticism of Shakespeare that we can gain further understanding of Wittgenstein's remarks on Shakespeare. These two points are related. For it seems to me that it is partly through his reflections on Tolstoy's theories about art that Wittgenstein is led into commenting upon Shakespeare.Tolstoy famously attacks Shakespeare in his pamphlet, "Shakespeare and the Drama,"4 published in 1903 when Tolstoy was seventy-five years of age. Some have taken this essay as evidence that Tolstoy was in his dotage, his mind warped by religious-moralistic fervor. Not only does this fail to do justice to Tolstoy's reasons for criticizing Shakespeare—reasons that Howard Mounce has recently argued are by no means ridiculous5 —it also neglects the fact that the essay is the culmination of Tolstoy's life-long antagonism to Shakespeare. Nevertheless, that very slur on Tolstoy's sanity attests to Shakespeare's status in our culture as something tremendous. His achievement is a standard against which others are measured. And this, I think, is at least partly what Wittgenstein is hinting at in his remarks about the contrast between the tremendous and the non-tremendous in art when he says of the tremendous that "it plays an entirely different role... (shrink)

A detailed discussion of issues in philosophical counseling for the practitioner and general public.

"Surrender; therefore, surrender or fight" is apparently an argument corresponding to an inference from an imperative to an imperative. Several philosophers, however (Williams 1963; Wedeking 1970; Harrison 1991; Hansen 2008), have denied that imperative inferences exist, arguing that (1) no such inferences occur in everyday life, (2) imperatives cannot be premises or conclusions of inferences because it makes no sense to say, for example, "since surrender" or "it follows that surrender or fight", and (3) distinct imperatives have conflicting permissive presuppositions (...) ("surrender or fight" permits you to fight without surrendering, but "surrender" does not), so issuing distinct imperatives amounts to changing one's mind and thus cannot be construed as making an inference. In response I argue inter alia that, on a reasonable understanding of 'inference', some everyday-life inferences do have imperatives as premises and conclusions, and that issuing imperatives with conflicting permissive presuppositions does not amount to changing one's mind. (shrink)

According to Hempel's paradox, evidence (E) that an object is a nonblack nonraven confirms the hypothesis (H) that every raven is black. According to the standard Bayesian solution, E does confirm H but only to a minute degree. This solution relies on the almost never explicitly defended assumption that the probability of H should not be affected by evidence that an object is nonblack. I argue that this assumption is implausible, and I propose a way out for Bayesians. Introduction Hempel's (...) paradox, the standard Bayesian solution, and the disputed assumption Attempts to defend the disputed assumption Attempts to refute the disputed assumption A way out for Bayesians Conclusion. (shrink)

I was quite excited when I first read Restall and Russell’s (2010) paper. For two reasons. First, because the paper provides rigorous formulations and formal proofs of implication barrier theses, namely “theses [which] deny that one can derive sentences of one type from sentences of another”. Second (and primarily), because the paper proves a general theorem, the Barrier Construction Theorem, which unifies implication barrier theses concerning four topics: generality, necessity, time, and normativity. After thinking about the paper, I am satisfied (...) with its treatment of the first three topics, namely generality, necessity, and time. But I am not satisfied with its treatment of normativity, so my comments are exclusively on that topic. (shrink)